研究報告 2025


原著論文
Liu, S., Mohri, S., Tsukamoto, M., Yanai, Y., Manabe, Y., Sugawara, T.
Preventive effects of dietary fucoxanthin on UVA-induced photoaging in hairless mice.
Journal of the Science of Food and Agriculture, 105, 453-464, 2025. https://doi.org/10.1002/jsfa.13842
Yamasaki, H., Ogawa, T., Manabe, Y., Sugawara, T., Tani, F.
Development of decolorization and degreasing reagents for optical clearing that enables visualization of the three-dimensional microstructure inside foods.
Journal of Food Composition and Analysis,
137(Part B), 106956, 2025. https://doi.org/10.1016/j.jfca.2024.106956
Liu, S., Manabe, Y., Sugawara, T.
Oral administration of astaxanthin mitigates chronological skin aging in mice.
Bioscience, Biotechnology, and Biochemistry, 89, 612-621, 2025. https://doi.org/10.1093/bbb/zbae205
Manabe, Y., Nitta, T., Ichihara, M., Maoka, T., Sugawara, T.
Dehydrometabolites of siphonaxanthin, a carotenoid from green algae, suppress TLR1/2-induced inflammatory response more strongly than siphonaxanthin.
Journal of Biological Chemistry, 301, 108246, 2025. https://doi.org/10.1016/j.jbc.2025.108246
Zheng J., Manabe Y., Sugawara T.
Preventive effect of siphonaxanthin, a carotenoid from green algae, against diabetic nephropathy and lipid metabolism insufficiency in skeletal muscle.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1870, 159604, 2025. https://doi.org/10.1016/j.bbalip.2025.159604
Kato, Y., Manabe, Y., Inoue, N., Nagao, K., Nagai, T., Sugawara, T.,
Anti-inflammatory function of ozonated ethyl ester of unsaturated fatty acids.
Journal of Oleo Sciences,
74, 495-501, 2025. https://doi.org/10.5650/jos.ess25040
Wakuda, N., Manabe, Y., Seko, T., Sugawara, T.
Different suppressive effects of canthaxanthin and fucoxanthin on cellular responses of human dermal fibroblasts to Ultraviolet A irradiation.
Bioscience, Biotechnology, and Biochemistry, 89, 1038-1044, 2025. https://doi.org/10.1093/bbb/zbaf056
 Manabe, Y., Ueda, M., Sugawara, T.  
β-Carotene suppresses lipopolysaccharide-induced nitric oxide production in microglia via retinoic acid receptor-dependent mechanism.
Journal of Oleo Science, 74, 845-857, 2025. https://doi.org/10.5650/jos.ess25072
Kavalappa, Y.P., Stephen, N.M., Jayalakshmi, B.K., Sugawara, T., Manabe, Y., Hirata, T., Ponesakki, G.
Siphonaxanthin inhibits the growth of breast cancer cell subtypes by modulating the expression of cellular proteins associated
with antioxidant defence, cell survival and apoptosis signaling.
Medical Oncology, 42, 259, 2025. https://doi.org/10.1007/s12032-025-02798-y
Tsuzuki, S., Yamasaki, M., Sugawara, T., Manabe Y., Toyoda, M., Mizutani, K., Sasaki, T.
Fatty amines and 1-monoglycerides with cytotoxic activity serve as ligands for a multipurpose receptor CD36.
Biomedical Research, 46,  189-202, 2025. https://doi.org/10.2220/biomedres.46.189



著書・総説など
Manabe, Y., Sugawara, T.,
Potential of siphonaxanthin, a green algal carotenoid, to prevent obesity and related diseases.
Journal of Natural Medicines, accepted for publication. https://doi.org/10.1007/s11418-025-01897-4
菅原達也, 食品スフィンゴ脂質の健康機能性, オレオサイエンス, 25, 389-396, 2025.
https://doi.org/10.5650/oleoscience.25.389
真鍋祐樹, カロテノイドの代謝変換研究, 化学と生物, 63, 398-400, 2025.
真鍋祐樹, マリンカロテノイドの生体内代謝と生物活性(機能性),
http://www.mac.or.jp/mail/251001/01.shtml